Combined ECT and clozapine in treatment-resistant mania

Abstract

A treatment-resistant manic patient failed to respond to conventional treatment, adjunctive olanzapine (20 mg/day), clozapine (600 mg/day), or ECT alone, but did respond to ECT combined with low dose clozapine (200 mg/day). Maintenance ECT combined with clozapine resulted in a remission over the 18-month period.